GW EMBERS Research Lab - Bilateral exploration in primary

Journal article

Tim Beck, Gustavo Romero‐Velez, S. Noureldine, Gilman Plitt, S. Wang, Judy Jin
American Journal of Surgery, 2024

Cite

APA Click to copy
Beck, T., Romero‐Velez, G., Noureldine, S., Plitt, G., Wang, S., & Jin, J. (2024). Bilateral exploration in primary hyperparathyroidism: Double adenoma distribution and biochemical patterns over two decades. American Journal of Surgery.

Chicago/Turabian Click to copy
Beck, Tim, Gustavo Romero‐Velez, S. Noureldine, Gilman Plitt, S. Wang, and Judy Jin. “Bilateral Exploration in Primary Hyperparathyroidism: Double Adenoma Distribution and Biochemical Patterns over Two Decades.” American Journal of Surgery (2024).

MLA Click to copy
Beck, Tim, et al. “Bilateral Exploration in Primary Hyperparathyroidism: Double Adenoma Distribution and Biochemical Patterns over Two Decades.” American Journal of Surgery, 2024.

BibTeX Click to copy

@article{tim2024a,
  title = {Bilateral exploration in primary hyperparathyroidism: Double adenoma distribution and biochemical patterns over two decades.},
  year = {2024},
  journal = {American Journal of Surgery},
  author = {Beck, Tim and Romero‐Velez, Gustavo and Noureldine, S. and Plitt, Gilman and Wang, S. and Jin, Judy}
}

Abstract

BACKGROUND We investigated if anatomic patterns of abnormal parathyroid glands have ch anged for primary hyperparathyroidism (pHPT) as atypical biochemical presentation (normohormonal and normocalcemic) has increased.

METHODS Retrospective review of patients with pHPT who underwent routine bilateral neck exploration.

RESULTS 2762 patients were included. The "late" cohort (2014-2020) exhibited lower preoperative calcium (10.8 vs 11.1 mg/dL; P = 0.001) and PTH levels (101 vs. 146 pg/mL; P = 0.001) compared to the "early" cohort (2000-2006). Patients with atypical biochemical profiles increased from 25.5% to 31.3% (P < 0.001). The prevalence of single adenoma (SA) decreased (66.1% vs 58.9%, P = 0.02) while the proportion of double adenoma (DA) increased (17.3% vs. 22.6%, P < 0.01). Upper parathyroid adenoma(s) remained the most common finding for SA and DA in both time points.

CONCLUSIONS Despite changes in patient characteristics, single upper adenoma and bilateral double upper adenomas remain the most common findings for patients with pHPT.